EXAMINE THIS REPORT ON SDZ 220-040

The impairment of HMGB1 functionality results in greater mitochondrial DNA damage. During the SCA1 mouse design, around-expression in the HMGB1 protein through an launched virus vector bearing the HMGB1 gene facilitates repair service from the mitochondrial DNA injury, ameliorates the neuropathology and the motor deficits, and extends the lifespan